Nutrition and cancer
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Nutrition and cancer · Jul 2017
Meta AnalysisVitamin B6 Intake and the Risk of Colorectal Cancer: A Meta-Analysis of Prospective Cohort Studies.
We performed this meta-analysis to estimate the association between vitamin B6 intake and colorectal cancer risk. ⋯ This meta-analysis provides evidence of a nonsignificant decrease in colorectal cancer risk associated with the high level of vitamin B6 intake, but the risk in dose-response analysis is significant. However, the latter finding is based on a limited number of studies, which should be interpreted with caution.
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Nutrition and cancer · Jan 2015
Meta AnalysisCoffee consumption and prostate cancer risk: a meta-analysis of cohort studies.
This meta-analysis was conducted to assess the association between coffee consumption and prostate cancer risk. Thirteen cohort studies with 34,105 cases and 539,577 participants were included in the meta-analysis. The summary relative risks (RRs) with 95% confidence intervals (CIs) for different coffee intake levels were calculated. ⋯ In subgroup analysis of prostate cancer grade, the summary RRs were 0.89 (95% CI: 0.83-0.96) for nonadvanced, 0.82 (95% CI: 0.61-1.10) for advanced and 0.76 (95% CI: 0.55-1.06) for fatal diseases. Our findings suggest that coffee consumption may be associated with a reduced risk of prostate cancer and it also has an inverse association with nonadvanced prostate cancer. Because of the limited number of studies, more prospective studies with large sample size are needed to confirm this association.
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Nutrition and cancer · Jan 2012
Meta AnalysisSelenium and colorectal adenomas risk: a meta-analysis.
Selenium, as an important component of some antioxidants, has been suggested to have protective effects against colorectal adenomas. This meta-analysis examined the association between selenium level in blood and risk of colorectal adenomas. Data from 7 studies (3 cross-sectional studies, 3 case-control studies, 1 nested case-control study) published before December 2011 was included in this meta-analysis. ⋯ Heterogeneity was moderate among the pooled studies (P = 0.05 for the Q test, I (2) = 48%). These results suggested a protective effect of selenium for colorectal adenomas. Some factors, such as age, gender, smoking, and characteristics of the adenomas need to be further considered within the association between selenium levels and risk of colorectal adenomas.
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Nutrition and cancer · Jan 2012
Meta AnalysisEstimation of cancer incidence and mortality attributable to overweight, obesity, and physical inactivity in China.
The objective was to provide an evidence-based, systematic assessment of the burden of cancer due to overweight/obesity and physical inactivity in China. This study evaluated the proportion of cancers of colon, rectum, pancreas, breast (postmenopausal), endometrium, and kidney attributable to overweight [30 kg/m(2) > body mass index (BMI) ≥ 25 kg/m(2))/obesity (BMI ≥ 30 kg/m(2)) and physical inactivity in China in 2005. Data of prevalence of overweight/obesity and lack of physical activity were derived from cross-sectional surveys among representative samples of Chinese population, and data of relative risks on cancers were derived from meta-analyses or large-scale studies from China and East Asian populations. ⋯ The largest increased attributable fractions will be for endometrial cancer. The increase in attributable fractions would be greater in men and in rural populations. Although the current burden of cancer associated with overweight/obesity and physical inactivity is still relatively small in China, it is expected to increase in the future.
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Nutrition and cancer · Nov 2011
Meta AnalysisEffects of selenium supplements on cancer prevention: meta-analysis of randomized controlled trials.
This meta-analysis aimed to investigate the preventive effect of selenium supplements alone on cancer as reported by randomized controlled trials (RCTs). We searched PubMed, EMBASE, and the Cochrane Library in July 2009. ⋯ Among subgroup meta-analyses, the preventive effect of selenium supplementation alone on cancer was apparently observed in populations with a low baseline serum selenium level (<125.6 ng/mL) (RR = 0.64; 95% CI = 0.53 to 0.78; I(2) = 45.5%; n = 7) and in high-risk populations for cancer (RR = 0.68; 95% CI = 0.58 to 0.80; I(2) = 41.5%; n = 8). The meta-analysis of randomized controlled trials indicates that there is possible evidence to support the use of selenium supplements alone for cancer prevention in the low baseline serum selenium level population and in the high-risk population for cancer.