Neurological research
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Neurological research · Feb 2021
Dexmedetomidine improves postoperative neurocognitive disorder after cardiopulmonary bypass in rats.
To investigate whether dexmedetomidine can improve postoperative neurocognitive function after cardiopulmonary bypass in rats. ⋯ Dexmedetomidine plays a neuroprotective role by inhibiting inflammation, apoptosis, and microglia activation in the prefrontal cortex and hippocampal DG region, and attenuates the cognitive deficit identified in the control group.