Journal of neuroscience methods
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J. Neurosci. Methods · Sep 2007
Automatic spike detection based on adaptive template matching for extracellular neural recordings.
Recordings of extracellular neural activity are used in many clinical applications and scientific studies. In most cases, these signals are analyzed as a point process, and a spike detection algorithm is required to estimate the times at which action potentials occurred. ⋯ The algorithm iteratively estimates the morphology of the most prominent action potentials. It is able to achieve a sensitivity of >90% with a false positive rate of <5Hz in recordings with an estimated SNR=3, and it performs better than an optimal threshold detector in recordings with an estimated SNR>2.5.
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J. Neurosci. Methods · Sep 2007
Randomized Controlled Trial Comparative StudyA comparative study of the effects of repetitive paired transcranial magnetic stimulation on motor cortical excitability.
Various methods of application of repetitive transcranial magnetic stimulation (TMS) have been evaluated for their potential capacity to alter motor cortical excitability. Initial research suggests that the repetitive application of paired TMS pulses (repetitive paired pulse TMS (rppTMS)) may have greater effects on cortical excitability, perhaps through the facilitation of I-wave interaction. We aimed to compare the post-train effects of 15 min trains of rppTMS to investigate the potential therapeutic application of this technique as well as to compare it to a standard high frequency repetitive TMS paradigm. ⋯ Fifteen minutes trains of 1.5ms rppTMS do not substantially increase post train cortical excitability. Repetitive brief trains of 5Hz rTMS also do not alter excitability but appear to effect cortical inhibition.