Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Oct 1994
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialRelief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream. The Doxepin Study Group.
Atopic dermatitis is associated with severe pruritus for which effective topical treatment is lacking. As a potent H1 and H2 antagonist, the antipruritic effect of topical doxepin was first demonstrated in histamine-induced itch in nonatopic volunteers. ⋯ Topical doxepin is effective in reducing pruritus in patients with atopic dermatitis. It has an apparent short-term low risk of major side effects or sensitization.