Antimicrobial agents and chemotherapy
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Antimicrob. Agents Chemother. · Mar 2004
Randomized Controlled Trial Clinical TrialEarly bactericidal activity of moxifloxacin in treatment of pulmonary tuberculosis: a prospective, randomized study.
Moxifloxacin is the most active fluoroquinolone against Mycobacterium tuberculosis in vitro. However, data about the efficacy in patients are not available. ⋯ The calculated early bactericidal activities for isoniazid and moxifloxacin were 0.209 and 0.273 log(10) CFU per ml of sputum per day, respectively. According to the data from our study, moxifloxacin exhibits an early bactericidal activity that is comparable to that of isoniazid.