Methods and findings in experimental and clinical pharmacology
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Methods Find Exp Clin Pharmacol · Apr 2000
Randomized Controlled Trial Clinical TrialEffects of the NMDA receptor antagonist ketamine in electrically induced A delta-fiber pain.
Both ketamine and pethidine have previously been found to have analgesic effects in experimentally induced C-fiber pain. The aim of the present study was to examine the effects of ketamine and pethidine in A delta-fiber-mediated pain induced by electrical tooth stimulation. ⋯ Ketamine and pethidine have only a marginal effect on pain thresholds in electrically induced A delta-fiber-mediated tooth pulp pain, in contrast to the analgesic effects previously found in experimental and postoperative C-fiber-mediated pain. The ketamine enantiomers at the doses used in this study showed equal analgesic properties but different side effect profiles.