Methods and findings in experimental and clinical pharmacology
-
Methods Find Exp Clin Pharmacol · Oct 2006
Randomized Controlled Trial Multicenter StudyImpact of ibuprofen administration on renal drug clearance in the first weeks of life.
The administration of ibuprofen or any other nonselective cyclooxygenase (COX) inhibitor drug in early neonatal life is associated with a reduction of glomerular filtration, which reduces the elimination of drugs dependent on renal function for clearance. However, the relationship between COX inhibitor drug indication (prophylactic or therapeutic) and the magnitude of this effect remains unclear. ⋯ A significant and clinically relevant reduction in drug clearance is observed when ibuprofen is coadministered independent of indication, postmenstrual or postnatal age. Population modeling with covariate analyses can provide us with the tools to further disentangle the impact of nonselective COX-inhibitors on renal drug clearance.