Journal of clinical gastroenterology
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J. Clin. Gastroenterol. · May 2010
Randomized Controlled Trial Multicenter Study Comparative StudyA randomized, double-blind, phase 3 study of fospropofol disodium for sedation during colonoscopy.
This double-blind, multicenter study evaluated the safety and efficacy of intravenous fospropofol (6.5 mg/kg vs. 2 mg/kg) for moderate sedation in patients undergoing colonoscopy. ⋯ The fospropofol 6.5-mg/kg dosing regimen was well tolerated and effective for sedation during colonoscopy and was associated with higher rates of sedation success, memory retention, and physician satisfaction than the fospropofol 2-mg/kg dose.