Journal of clinical gastroenterology
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J. Clin. Gastroenterol. · Apr 2012
Soluble urokinase plasminogen activator receptor is associated with progressive liver fibrosis in hepatitis C infection.
Progressive liver fibrosis is the main predictor of disease outcome in chronic hepatitis C viral (HCV) infection. Although the importance of the coagulation cascade has been suggested in liver fibrogenesis, the role of the fibrinolytic pathway is yet unclear. ⋯ Serum suPAR levels were robust markers of liver fibrosis in 2 cohorts with a comparable diagnostic accuracy for prediction of severe liver fibrosis as established noninvasive marker.