Journal of clinical gastroenterology
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J. Clin. Gastroenterol. · Nov 2004
Randomized Controlled Trial Comparative Study Clinical TrialA randomized controlled trial of gastric lavage prior to endoscopy for acute upper gastrointestinal bleeding.
We hypothesized that large volume gastric lavage prior to endoscopy for acute upper gastrointestinal bleeding would improve the quality of endoscopic examination. ⋯ Large volume gastric lavage prior to esophagogastroduodenoscopy for acute upper gastrointestinal bleeding is safe and provides better visualization of the gastric fundus.
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J. Clin. Gastroenterol. · Aug 2004
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialParecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects.
The gastrointestinal safety of the novel injectable cyclooxygenase-2 selective inhibitor, parecoxib sodium, was compared with the nonselective nonsteroidal anti-inflammatory drug, ketorolac, and placebo in healthy subjects. ⋯ Parecoxib sodium 40 mg twice daily for 7 days has a gastrointestinal safety profile superior to ketorolac 30 mg 4 times daily for 5 days, and comparable to placebo.
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J. Clin. Gastroenterol. · May 2004
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialSafety of sodium phosphate tablets in patients receiving propofol-based sedation for colonoscopy.
To compare the incidence of peri-procedure adverse events in patients undergoing colon cleansing with sodium phosphate tablets or polyethylene glycol solution prior to colonoscopy with propofol-based sedation. ⋯ Peri-procedure adverse events occurred rarely and with no increased frequency in patients using the sodium phosphate tablet purgative and receiving propofol-based sedation. The sodium phosphate tablet purgative is safe for patients receiving propofol-based sedation for colonoscopy.
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J. Clin. Gastroenterol. · Jul 1999
Randomized Controlled Trial Comparative Study Clinical TrialSulpiride versus metoclopramide in nononcologic patients with vomiting or nausea.
Metoclopramide, a benzamide substitute, is used frequently as an antiemetic drug. Sulpiride, another benzamide substitute, was investigated and found to be safe and effective in a handful of studies involving only oncologic or other severely symptomatic patients. In this investigation the authors compared prospectively the antiemetic efficacy of sulpiride versus metoclopramide in a double-blind, randomized study involving 36 nononcologic patients with transient vomiting or nausea of various etiologies. ⋯ Efficacy of the two drugs proved similar, and at the end of the study, 14 and 13 of 18 patients on sulpiride or metoclopramide respectively were asymptomatic. Only transient, minor side effects were reported in one patient in each group. The authors conclude that sulpiride is an effective and safe antiemetic drug that can be adopted legitimately in such cases as a first choice, or serve as an equipotent alternative to metoclopramide in patients sensitive to the latter.
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J. Clin. Gastroenterol. · Jul 1999
Randomized Controlled Trial Clinical TrialPharmacokinetic interaction between acetaminophen and lansoprazole.
Because of its minimal gastric toxicity, acetaminophen is the analgesic of choice for patients with gastric acid-related disorders. Because proton pump inhibitors are widely used, concomitant prescription of acetaminophen and lansoprazole would be prevalent. This crossover study was conducted to investigate an acetaminophen-lansoprazole interaction. ⋯ The peak plasma concentration of acetaminophen and the time to its occurrence were significantly higher and shorter, respectively, during the lansoprazole session than during the control session. Neither the elimination half-life nor the area under the curve was significantly different between the two sessions. Lansoprazole hastens the absorption of acetaminophen solution, but little modifies its elimination rate and bioavailability.