Journal of reproductive immunology
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J. Reprod. Immunol. · Aug 2003
ReviewTrophoblast deportation and the maternal inflammatory response in pre-eclampsia.
We have proposed that the maternal syndrome of pre-eclampsia is caused by a systemic inflammatory response involving both leucocytes and endothelium. This inflammatory response is present also in normal pregnancy, but in a milder form. ⋯ Syncytiotrophoblast apoptotic debris, which is shed into the maternal circulation in normal pregnancy and in increased amounts in pre-eclampsia, may be the stimulus for this response. It may also contribute to the suppression of Th1 responses seen in pregnancy.