Annals of emergency medicine
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomized clinical trial of intravenous magnesium sulfate as an adjunctive medication for emergency department treatment of migraine headache.
We test the hypothesis that intravenous magnesium sulfate is an effective adjunctive medication for treatment of acute migraine. ⋯ Although this result was unexpected, our data suggest that the addition of magnesium to metoclopramide may attenuate the effectiveness of metoclopramide in relieving migraine. Countertherapeutic cerebral vasodilatation caused by magnesium is a plausible, although unproven, explanation for this finding. Because of the preponderance of women in our trial, these data may not be generalizable to men.