Annals of emergency medicine
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Large doses of intramuscular (IM) naloxone are commonly used in out-of-hospital settings to reverse opioid toxicity; however, they are used less commonly in hospitals because of concerns about opioid withdrawal, particularly agitation. We aimed to determine the frequency of severe agitation following a single 1.6 mg IM naloxone dose. ⋯ Severe agitation was uncommon following the administration of 1.6 mg IM naloxone and rarely required chemical sedation.