AJNR. American journal of neuroradiology
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AJNR Am J Neuroradiol · Oct 2013
Meta AnalysisMR imaging features of amyloid-related imaging abnormalities.
AD is one of the few leading causes of death without a disease-modifying drug; however, hopeful agents are in various phases of development. MR imaging abnormalities, collectively referred to as amyloid-related imaging abnormalities, have been reported for several agents that target cerebral Aβ burden. ARIA includes ARIA-E, parenchymal or sulcal hyperintensities on FLAIR indicative of parenchymal edema or sulcal effusions, and ARIA-H, hypointense regions on gradient recalled-echo/T2* indicative of hemosiderin deposition. This report describes imaging characteristics of ARIA-E and ARIA-H identified during studies of bapineuzumab, a humanized monoclonal antibody against Aβ. ⋯ In 49% of cases of ARIA-E, there was the associated appearance of ARIA-H. In treated patients without ARIA-E, the risk for incident blood products was 4%. This association between ARIA-E and ARIA-H may suggest a common pathophysiologic mechanism. Familiarity with ARIA should permit radiologists and clinicians to recognize and communicate ARIA findings more reliably for optimal patient management.
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AJNR Am J Neuroradiol · Sep 2013
Meta Analysis Comparative StudyCoil embolization versus clipping for ruptured intracranial aneurysms: a meta-analysis of prospective controlled published studies.
Coil embolization is an alternative to clipping for intracranial aneurysms. However, controversy exists regarding the best therapeutic strategy in patients with ruptured aneurysms, and there is great center- and country-related variability in the rates of clipping versus coiling. We performed a meta-analysis of prospective controlled trials of clipping versus coil embolization for ruptured aneurysms. ⋯ On the basis of the analysis of the 3 high-quality prospective controlled trials available, there is strong evidence to indicate that endovascular coil embolization is associated with better outcomes compared with surgical clipping in patients amenable to either therapeutic strategy.
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AJNR Am J Neuroradiol · Jan 2012
Review Meta AnalysisSafety and efficacy of balloon remodeling technique during endovascular treatment of intracranial aneurysms: critical review of the literature.
The balloon remodeling technique was initially designed for the endovascular treatment of anatomically complex aneurysms, specifically wide-neck aneurysms. A nondetachable balloon is inflated in front of the aneurysm neck during coil deposition and removed at the end of the procedure. ⋯ Anatomic results are also probably better after remodeling. Finally, due to equivalent safety and better anatomic results, the remodeling technique can be widely used in the management of both ruptured and unruptured aneurysms.
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AJNR Am J Neuroradiol · Nov 2010
Meta AnalysisDiagnostic accuracy of CT angiography and CT perfusion for cerebral vasospasm: a meta-analysis.
In recent years, the role of CTA and CTP for vasospasm diagnosis in the setting of ASAH has been the subject of many research studies. The purpose of this study was to perform a meta-analysis of the diagnostic performance of CTA and CTP for vasospasm in patients with ASAH by using DSA as the criterion standard. ⋯ The high diagnostic accuracy determined for both CTA and CTP in this meta-analysis suggests that they are potentially valuable techniques for vasospasm diagnosis in ASAH. Awareness of these results may impact patient care by providing supportive evidence for more effective use of CTA and CTP imaging in ASAH.
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AJNR Am J Neuroradiol · Oct 2010
Review Meta AnalysisKlippel-Trenaunay syndrome and spinal arteriovenous malformations: an erroneous association.
KTS is a rare limb overgrowth disorder with slow-flow vascular anomalies. This study examines the presumed association between KTS and spinal AVMs. ⋯ An association between KTS and spinal AVM, as posited in numerous references, is most likely erroneous. The association has neither been reliably proved in the limited published literature nor encountered in a large cohort.