American journal of infection control
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Am J Infect Control · Mar 2011
Randomized Controlled TrialAssociation of preservative-free propofol use and outcome in critically ill patients.
Propofol is widely used to provide sedation to patients in the intensive care unit (ICU). This study examined whether preservative-free propofol infusion independently influences outcome in critically ill patients. ⋯ Preservative-free propofol infusion in critically ill patients may be associated with increased risk of ICU-acquired infections and ICU-acquired sepsis, with no significant difference in ICU or hospital mortality. This association might have been related to the use of preservative-free preparations.