European heart journal
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European heart journal · Aug 2015
Randomized Controlled Trial Multicenter Study Comparative StudyMarfan Sartan: a randomized, double-blind, placebo-controlled trial.
To evaluate the benefit of adding Losartan to baseline therapy in patients with Marfan syndrome (MFS). ⋯ Losartan was able to decrease blood pressure in patients with MFS but not to limit aortic dilatation during a 3-year period in patients >10 years old. β-Blocker therapy alone should therefore remain the standard first line therapy in these patients.
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European heart journal · Aug 2015
Randomized Controlled Trial Multicenter Study Comparative StudyEffect of the angiotensin-receptor-neprilysin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients.
The angiotensin-receptor-neprilysin inhibitor (ARNI) LCZ696 reduced cardiovascular deaths and all-cause mortality compared with enalapril in patients with chronic heart failure in the prospective comparison of ARNI with an Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial. To more completely understand the components of this mortality benefit, we examined the effect of LCZ696 on mode of death. ⋯ https://clinicaltrials.gov/, NCT01035255.
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European heart journal · Aug 2015
Exercise-induced right ventricular dysfunction is associated with ventricular arrhythmias in endurance athletes.
Intense exercise places disproportionate strain on the right ventricle (RV) which may promote pro-arrhythmic remodelling in some athletes. RV exercise imaging may enable early identification of athletes at risk of arrhythmias. ⋯ Among athletes with normal cardiac function at rest, exercise testing reveals RV contractile dysfunction among athletes with RV arrhythmias. RV stress testing shows promise as a non-invasive means of risk-stratifying athletes.