Scandinavian journal of rheumatology
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Scand. J. Rheumatol. · Jan 2001
Randomized Controlled Trial Comparative Study Clinical TrialCelecoxib versus diclofenac in the management of osteoarthritis of the knee.
A clinical trial was conducted in 600 patients with OA of the knee to test the hypothesis that the specific COX-2 inhibitor, celecoxib, has equivalent efficacy and a superior tolerability/safety profile when compared to diclofenac, the current worldwide standard of care. ⋯ Celecoxib 200 mg daily is as effective as diclofenac 150 mg daily for relieving signs and symptoms of OA of the knee, including pain, and has a rapid onset of action. However, celecoxib appears to have a superior safety and tolerability profile.