Anticancer research
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Anticancer research · Sep 2016
Meta AnalysisPrognostic Role of BRAF Mutations in Colorectal Cancer Liver Metastases.
The impact of tumor biology on prognosis in patients with colorectal liver metastasis (CRLM) has been the topic of intense research. Specifically, the presence of BRAF mutations has been recently associated with adverse long-term outcomes. We examined the existing literature on the prognostic implications of BRAF mutations in patients with CRLM. ⋯ BRAF-mutant lesions are consistently associated with poor prognosis. Consequently, the indications of CRLM resection in this patient group should be reconsidered.