Pharmacotherapy
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Randomized Controlled Trial Comparative Study Clinical Trial
The effect of three different ranitidine dosage regimens on reducing gastric acidity and volume in ambulatory surgical patients.
To evaluate three different preoperative oral dosing regimens of ranitidine in ambulatory patients who had significant risk of aspiration pneumonitis (gastric pH < or = 2.5 or volume > or = 25 ml at intubation or extubation). ⋯ Ranitidine 150 mg twice/day preoperatively reduced to the greatest degree the percentage of patients who developed significant risk factors for aspiration pneumonitis after surgery under general anesthesia.