Pharmacotherapy
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Sedatives administered by continuous intravenous infusion are an essential component of the care of patients requiring mechanical ventilation. Delayed awakening from sedation has been associated with prolonged stays in the hospital and the intensive care unit (ICU). Incorporation of a daily sedation interruption policy into a medical ICU guideline has significantly reduced ICU stay and days of mechanical ventilation, and has significantly increased the likelihood of planned extubation compared with no intervention. ⋯ Resistance to the routine implementation of a daily sedation interruption policy arises from concerns about the need for greater resources and the risk of rebound agitation. The benefits have been documented only in a single center to date. However, the benefit: risk ratio is positive and warrants incorporation of daily sedation interruption into the routine care of patients who are critically ill and require mechanical ventilation.
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Adequate sleep, in terms of both quantity and quality, is an essential component of any overall health program. Sleep deprivation has serious deleterious effects on any subject, regardless of species. ⋯ The causes of sleep disturbance in the intensive care unit involve factors related to the underlying clinical condition, those due to the various drugs required to provide treatment and comfort, and those related to the environment and processes of care in the intensive care unit. Only through a comprehensive approach to intensive care can an environment that promotes sleep and revitalization be constructed and maintained.
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The bispectral index (BIS) is processed electroencephalographic technology used in concert with clinical evaluations to objectively evaluate a patient's level of consciousness and probability of recall. Although the BIS has been extensively studied in the operating room setting, differences in patient populations, goals of treatment, and the environments themselves necessitate the development of BIS data specific to the intensive care unit. Data have evolved over the last several years, but for many reasons, the results and conclusions have varied. ⋯ Some of these patients cannot be evaluated with such tools because they lack motor responsiveness due to therapeutic paralysis or because they are receiving deep sedation. Bispectral index scores that are higher than expected in clinically sedated patients can often be traced to electromyographic activity or to the possibility of inadequate sedation and analgesia. The BIS must not be regarded as the sole indicator of level of consciousness, but should be used as part of an integrated approach to the evaluation of carefully selected patients with critical illness.
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Propofol (2,6-diisopropylphenol) is a potent intravenous hypnotic agent widely administered for induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol is insoluble in water and therefore is formulated in a lipid emulsion. In addition, a preservative (ethylenediaminetetraacetic acid [EDTA] or sodium metabisulfite) is added to retard bacterial growth. ⋯ Propofol also is a potent antioxidant. The added preservatives have biologic activity; EDTA has antiinflammatory properties, whereas metabisulfite may cause lipid peroxidation. The antiinflammatory and antioxidant properties of propofol may have beneficial effects in patients with sepsis and systemic inflammatory response syndrome.
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Since the 2002 publication of multidisciplinary clinical practice guidelines for intensive care unit (ICU) sedation and analgesia, additional information regarding adverse drug events has been reported. Our understanding of the risks associated with these sedative and analgesic agents promises to improve outcomes by helping clinicians identify and respond to therapeutic misadventures sooner. This review focuses on many issues, including the potentially fatal consequences associated with the propofol infusion syndrome, the evolving understanding of propylene glycol intoxication associated with parenteral lorazepam, new data involving high-dose and long-term dexmedetomidine therapy, haloperidol- and methadone-related prolongation of QTc intervals on the electrocardiogram, adverse events associated with atypical antipsychotics, and the potential for nonsteroidal antiinflammatory drugs to interfere with bone healing.