Pharmacotherapy
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Randomized Controlled Trial
The effect of acetaminophen on the international normalized ratio in patients stabilized on warfarin therapy.
To determine whether an interaction exists between acetaminophen and warfarin that alters the international normalized ratio (INR). ⋯ These findings support the existence of a clinically significant interaction between warfarin and daily use of acetaminophen 2-4 g, necessitating close monitoring of patients who receive this drug combination. Whether this interaction occurs when acetaminophen is taken in lower doses or is used sporadically requires further study.