Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas
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Braz. J. Med. Biol. Res. · Jan 1989
Randomized Controlled Trial Comparative Study Clinical TrialPerspectives on clinical trials for hypertonic saline/dextran solutions for the treatment of traumatic shock.
Animal studies with hypertonic solutions suggest that they can achieve resuscitation of hypovolemic shock with extremely small volumes. Such small volume resuscitation might be ideal in the field treatment of injured patients. ⋯ The solutions have been safe, and we have encountered no adverse side effects from their use. Survival rates to date favor use of the solutions, but we do not have convincing statistical significance yet in that regard.