Cephalalgia : an international journal of headache
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Randomized Controlled Trial
The effect of sumatriptan on cephalic arteries: A 3T MR-angiography study in healthy volunteers.
To explore a possible differential effect of sumatriptan on extracerebral versus cerebral arteries, we examined the superficial temporal (STA), middle meningeal (MMA), extracranial internal carotid (ICAextra), intracranial internal carotid (ICAintra), middle cerebral (MCA) and basilar arteries (BA). ⋯ Sumatriptan constricts extracerebral arteries more than cerebral arteries. We suggest that sumatriptan may exert its anti-migraine action outside of the blood-brain barrier.