Cephalalgia : an international journal of headache
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The objective of this article is to review the prospect of treating migraine with sphenopalatine ganglion (SPG) neurostimulation. ⋯ We propose two possible mechanisms of action: 1) interrupting the post-ganglionic parasympathetic outflow to inhibit the pain and cephalic autonomic symptoms, and 2) modulating the sensory processing in the trigeminal nucleus caudalis. To further explore SPG stimulation in migraineurs as regards therapeutic potential and mode of action, randomized clinical trials are warranted.