Cephalalgia : an international journal of headache
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Randomized Controlled Trial
Eptinezumab for prevention of chronic migraine: A randomized phase 2b clinical trial.
Calcitonin gene-related peptide plays an important role in migraine pathophysiology. We evaluated eptinezumab, an intravenous (IV) anti-calcitonin gene-related peptide monoclonal antibody, for the prevention of chronic migraine. ⋯ The results of this trial demonstrate that eptinezumab appears effective and well-tolerated for the preventive treatment of chronic migraine and justifies the conduct of pivotal phase 3 trials for migraine prevention.