Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
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J. Oral Maxillofac. Surg. · Jun 1999
Additive analgesic effects of oxycodone and ibuprofen in the oral surgery model.
A traditional approach to achieve greater analgesic efficacy is to combine an efficacious dose of a nonopioid with a dose of an opioid sufficient to produce additive analgesia without a substantial increase in the incidence of adverse effects. This study evaluated the additive analagesic effects of the combination of ibuprofen and oxycodone. ⋯ These results indicate that additive analgesia can be achieved for the combination of a nonsteroidal anti-inflammatory drug and an orally effective opioid, with faster onset of relief for the combination of 400 mg ibuprofen and 10 mg oxycodone over the first 2 hours after administration, but at the expense of an increased incidence of adverse events.
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J. Oral Maxillofac. Surg. · May 1999
Randomized Controlled Trial Comparative Study Clinical TrialBupivacaine versus lidocaine for third molar surgery: a double-blind, randomized, crossover study.
The aim of this study was to compare the clinical use of bupivacaine to lidocaine in third molar surgery. ⋯ The results of this study do not show a difference in a variety of parameters, other than postoperative pain experience, when bupivacaine and lidocaine are compared in a standardized oral surgery procedure.
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J. Oral Maxillofac. Surg. · Apr 1999
The in vitro evaluation of a local pedicled osteomyocutaneous mandibular flap for the reconstruction of composite mandibular defects.
The purpose of this study was to develop and assess the potential feasibility of reconstructing composite defects of the mandible with a local pedicled osteomyocutaneous mandibular flap. ⋯ The pedicled osteomyocutaneous mandibular flap appears to have a sound anatomic basis. Clinical evaluation is needed to fully elucidate its potential role in head and neck reconstruction.