Progress in neuro-psychopharmacology & biological psychiatry
-
Prog. Neuropsychopharmacol. Biol. Psychiatry · Jan 2013
Randomized Controlled TrialNeural mechanism of placebo effects and cognitive reappraisal in emotion regulation.
The present study compared learning-based placebo effect and cognition-based reappraisal, to reveal the common and unique neural mechanisms between the two emotion regulations. First, the anxiety-relieving effect was tested by conducting a behavioral experiment. ⋯ Our results show that learning-based placebo effect and cognition-based reappraisal have common anxiety-relieving effects. The placebo effect mainly depends on direct pathway subgenual cingulate-amygdala to regulate emotions, whereas the reappraisal may rely on both indirect pathways, such as the dorsal PFC-subgenual cingulate-amygdala, and direct pathways, such as the ventral lateral PFC-amygdala to regulate emotions.