Progress in neuro-psychopharmacology & biological psychiatry
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Prog. Neuropsychopharmacol. Biol. Psychiatry · Jan 1987
ReviewLimbic postictal events: anatomical substrates and opioid receptor involvement.
1. Amygdaloid kindled seizures in rats produce postictal motor deficits, disruption of affective responding to sensory input, postictal explosiveness, and seizure suppression that may be similar to events following complex partial seizures in humans. 2. Preliminary 2DG studies in kindled rats indicate that postictal motor deficits may be mediated by the substantia nigra. ⋯ Kindling-induced postictal seizure suppression may be mediated by kappa receptors and perhaps also by mu receptors. 4. Mechanisms underlying postictal effects of complex partial seizures in humans are suggested by the data in this manuscript. New approaches to the treatment of these postictal events are also proposed.
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Pain is a complex physiological phenomenon that begins with the stimulation of free nerve endings in peripheral tissues and culminates in the perception of a physical and psychological state. The pain experience may be facilitated or inhibited through the action of several neurologic circuits which utilize several neurotransmitters. Therapeutic analgesia is achieved either through interference with pain-facilitating mechanisms or enhancement of pain-inhibiting mechanisms; practical applications are reviewed.