Thrombosis research
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Thrombosis research · Jul 2014
Multicenter Study Observational StudySustained high plasma plasminogen activator inhibitor-1 levels are associated with severity and mortality in septic patients.
Higher plasma plasminogen activator inhibitor-1 (PAI-1) levels have been reported in septic patients. However, some questions remain unanswered, such as whether there is an association between plasma PAI-1 levels and sepsis severity and mortality, and inflammation state during the first week. ⋯ The most interesting findings of our study, to our knowledge the largest series reporting PAI-1 levels during follow-up in septic patients, were that plasma PAI-1 levels during the first week were associated with inflammation, severity and mortality.