Annales françaises d'anesthèsie et de rèanimation
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Ann Fr Anesth Reanim · Jun 2002
Review[Sedation induced by midazolam in intensive care: pharmacologic and pharmacokinetic aspects].
Review on midazolam in order to optimize drug utilisation and therapeutic monitoring. ⋯ According to midazolam pharmacokinetic and pharmacodynamic variability, an individual dosage adjustment is essential for long-term sedation. Target controlled sedation could be a mean to limit the variability and to reach quickly the pharmacodynamic effect.
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Ann Fr Anesth Reanim · Jun 2002
Review[The pharmacology of cannabinoid derivatives: are there applications to treatment of pain?].
To present the cannabinoid system together with recent findings on the pharmacology of these compounds in the treatment of pain. ⋯ The cannabinoid system is a major target in the treatment of pain and its therapeutic potential should be assessed in the near future by the performance of new clinical trials.
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Ann Fr Anesth Reanim · Jun 2002
[Contraction-relaxation coupling of skeletal muscle in patients susceptible to malignant hyperthermia].
To assess whether halothane exposure could influence contraction-relaxation coupling of human skeletal muscle with malignant hyperthermia susceptibility. STUDY DESIGNED: Laboratory investigation. ⋯ Our results indicated that, in MHN muscle the contractility property is improved with halothane exposure. In MHS muscle, halothane caused an impairment of relaxation. The mechanical abnormalities observed in this study might be related to sarcoplasmic reticulum dysfunction in MH diseases.
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Ann Fr Anesth Reanim · Jun 2002
[Does the time between preoperative interruption of aspirin intake and operation influence postoperative blood loss and transfusion requirement in coronary artery bypass graft?].
Impact of the interval between interruption of aspirin intake and surgery on postoperative bleeding and transfusion in coronary artery bypass graft (CABG), with extracorporeal circulation (ECC). ⋯ Our study showed that in our practice using systematic low dose of aprotinin when priming the ECC circuit, aspirin did not significantly increase bleeding or transfusion requirements in CABG with ECC, whatever the interval between interruption of aspirin intake and surgery. Consequently, in our practice, aspirin intake is interrupted on hospitalisation, one day before surgery.