Annales françaises d'anesthèsie et de rèanimation
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Ann Fr Anesth Reanim · Jun 2002
Review[Sedation induced by midazolam in intensive care: pharmacologic and pharmacokinetic aspects].
Review on midazolam in order to optimize drug utilisation and therapeutic monitoring. ⋯ According to midazolam pharmacokinetic and pharmacodynamic variability, an individual dosage adjustment is essential for long-term sedation. Target controlled sedation could be a mean to limit the variability and to reach quickly the pharmacodynamic effect.
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Ann Fr Anesth Reanim · Jun 2002
Review[The pharmacology of cannabinoid derivatives: are there applications to treatment of pain?].
To present the cannabinoid system together with recent findings on the pharmacology of these compounds in the treatment of pain. ⋯ The cannabinoid system is a major target in the treatment of pain and its therapeutic potential should be assessed in the near future by the performance of new clinical trials.
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Ann Fr Anesth Reanim · Jun 2002
[Contraction-relaxation coupling of skeletal muscle in patients susceptible to malignant hyperthermia].
To assess whether halothane exposure could influence contraction-relaxation coupling of human skeletal muscle with malignant hyperthermia susceptibility. STUDY DESIGNED: Laboratory investigation. ⋯ Our results indicated that, in MHN muscle the contractility property is improved with halothane exposure. In MHS muscle, halothane caused an impairment of relaxation. The mechanical abnormalities observed in this study might be related to sarcoplasmic reticulum dysfunction in MH diseases.
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Ann Fr Anesth Reanim · Jun 2002
Clinical Trial[Laparoscopic adrenalectomy for pheochromocytoma. Perioperative blockade with urapidil].
To investigate the effects of coeliosurgery by catecholamine assays and the use of urapidil in the management of phaeochromocytoma. ⋯ Perioperative alpha 1 blockade by urapidil enables an effective and easy control of acute preoperative haemodynamic changes.
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Ann Fr Anesth Reanim · Jun 2002
Case Reports[Spontaneous thrombosis of an iatrogenic pseudoaneurysm of the arterial brachiocephalic trunk following central venous catheterization].
Following the unsuccessful puncture of the right subclavian vein during central catheterism, a 80-year-old women developed a pseudoaneurysm on the external face of the brachiocephalic artery. Her symptomatology and haemodynamic status having remained steady, the patient was closely observed. The pseudoaneurysm itself thrombosed spontaneously and the foreseen endovascular procedure doesn't have been achieved. A review of the literature has been done concerning the venous catheterism complications and the pseudoaneurysm treatment.