Annales françaises d'anesthèsie et de rèanimation
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Ann Fr Anesth Reanim · Jan 2005
Randomized Controlled Trial Clinical Trial[Analgesic effect of continuous intravenous nefopam after urological surgery].
To evaluate the efficacy of continuous infusion of nefopam. Indeed this analgesic is commonly used by continuous infusion by many anaesthetists to reduce its adverse effects. However whether the analgesic effect of an intermittent administration of nefopam has been proven, the efficacy of continuous infusion has not been established. ⋯ In this study, continuous administration of nefopam did not reduce morphine consumption nor ameliorate analgesia and thus may not be recommended in urological surgery. Nefopam pharmacokinetics when used with continuous infusion as well as surgery types and differences in age between groups may explain these results.