Annales françaises d'anesthèsie et de rèanimation
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Ann Fr Anesth Reanim · Dec 2008
Interest of BIS monitoring to guide propofol infusion during the anhepatic phase of orthotopic liver transplantation.
The anhepatic phase of orthotopic liver transplantation (OLT) is associated with significant changes in pharmacokinetics. The aim of this study was to compare the influence of this phase on propofol target concentrations during BIS guided target controlled infusion (TCI). ⋯ BIS could be useful to titrate propofol infusion during the anhepatic phase of OLT.
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Ann Fr Anesth Reanim · Dec 2008
Review Comparative Study[Rivaroxaban (Xarelto): efficacy and safety].
The oral direct Xa inhibitor rivaroxaban (Xarelto) shows great promise for prevention of venous thromboembolic events after major elective orthopedic surgery. Its consistent and predictable pharmacokinetics and pharmacodynamics across a wide range of patient populations allow administration with fixed dosing and with no coagulation monitoring. In 4 orthopaedic surgery clinical trials (12,700 patients), 10mg postoperative (6-10 hours after the end of surgery) dose, once daily, of oral rivaroxaban, achieved superior efficacy and similar safety to enoxaparin, whatever the dose of enoxaparin. ⋯ Although the risk of spinal haematoma after neuraxial anaesthesia is rare, it is increased by concomitant use of anticoagulants. In orthopedic surgery trials with rivaroxaban to date, complications such as spinal haematoma have not been reported. The pharmacokinetic profile of rivaroxaban suggests that concurrent use with neuraxial anaesthesia should require no further precautions than currently necessary with low-molecular-weight heparin.
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Ann Fr Anesth Reanim · Dec 2008
Randomized Controlled Trial[Effect of ketamine on prevention of postmastectomy chronic pain. A pilot study].
This pilot study was designed to evaluate the feasibility of a trial to estimate the preventive effect of ketamine on postmastectomy pain syndrome (PMPS). ⋯ We found no preventive effect of ketamine on the development of PMPS. However, the non-statistically significant effect of ketamine on hyperalgesia three months after surgery could justify a larger study with the same methodology.
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Ann Fr Anesth Reanim · Dec 2008
Randomized Controlled Trial[Ropivacaine infiltration during breast cancer surgery: postoperative acute and chronic pain effect].
Decrease acute pain after breast cancer surgery by an infiltration of ropivacaine. Analyse effect on chronic pain. ⋯ Ropivacaine scar infiltration provided no acute or chronic pain relief after breast cancer surgery.