Annales françaises d'anesthèsie et de rèanimation
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Ann Fr Anesth Reanim · Jun 2010
Review[Lipid emulsions for the treatment of systemic local anesthetic toxicity: Efficacy and limits].
Local anaesthetic toxicity always results from rapid and important increase in their plasma concentrations. Clinically, neurologic and cardiovascular symptoms may occur, especially life-threatening cardiac arrhythmias and cardiac depression. ⋯ The present article is a mini-review of the current use of lipid emulsions for the treatment of local anaesthetic cardiac toxicity. The mechanisms of cardiac toxicity and those of lipid emulsion therapy are summarized, and the clinical experience of this therapy and its limits are presented.
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To expose the current knowledge about the anaesthetic effects on the developing brain. ⋯ This review raises the question of the innocuity of anaesthetic agents on the developing brain; further clinical trials are required in order to test this effect on human babies.