Annales françaises d'anesthèsie et de rèanimation
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Ann Fr Anesth Reanim
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Hypernatremia is defined by a serum sodium concentration of more than 145 mmol/L and reflects a disturbance of the regulation between water and sodium. The high incidence of hypernatremia in patients with severe brain injury is due various causes including poor thirst, diabetes insipidus, iatrogenic sodium administration, and primary hyperaldosteronism. ⋯ Because of the rapid brain adaptation to extracellular hypertonicity, sustained hypernatremia exposes the patient to an exacerbation of brain edema during attempt to normalize natremia. Like serum glucose, serum sodium concentration must be tightly monitored in the intensive care unit.
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Ann Fr Anesth Reanim · Jun 2014
Letter Case Reports[Diffuse encephalitis and coma on isotretinoin treated patient.]