Annales françaises d'anesthèsie et de rèanimation
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Ann Fr Anesth Reanim · Jan 2013
Review[Cerebral near-infrared spectroscopy (NIRS) in paediatric anaesthesia].
Cerebral oximetry allows continuous real-time and non-invasive monitoring of cerebral oxygen saturation (cSO(2)), by measuring oxyhaemoglobin and deoxyhaemoglobin near infrared light absorption, similarly to pulse oximetry. cSO(2) measurement predominantly reflects brain venous compartment, and is correlated with jugular venous saturation. As jugular venous saturation, cSO(2) must therefore be interpreted as a measure of balance between transport and consumption of O(2) in the brain. ⋯ In children, the occurrence of intra- and postoperative cerebral desaturations during congenital heart surgery is associated with increased neurological morbi-mortality. Cerebral oximetry could be a useful monitoring during anaesthesia of (ex) preterm neonates, due to the risk of impaired cerebral blood flow autoregulation in these patients.
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For several years, total intravenous anaesthesia (TIVA) has demonstrated many advantages that allow considering propofol anaesthesia as an interesting alternative in pediatric anaesthesia. TCI in children requires calculation and validation of pharmacokinetic (PK) models specifically adapted to the paediatric population. Several PK models based on a 3-compartement approach have been proposed in children: all these models, which integrate only weight as covariable, show increased distribution volumes with a wide interindividual variability. ⋯ However, as pharmacodynamic (PD) parameters are still debated in children, there is up to now, no PKPD model currently available for paediatric anaesthesia. Schnider et al.'s model, a model described in adults that includes numerous covariables, may be adapted and more efficient than the classical paediatric models to describe propofol-PKPD relationship in children over 5years. Whatever the model, a pharmacodynamic feedback such as the bispectral index may be useful to counteract interindividual variability in the paediatric population.
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Ann Fr Anesth Reanim · Jan 2013
Review[Regional anesthesia for postoperative analgesia at home in children].
Hospitalization at home has known for the past few years a growing interest in care of patients. It has shown its advantages in children in terms of reducing the stress of parental separation, postoperative infections and the cost of hospitalization. But, pain remains the most common complaint in the postoperative follow-up of patients. ⋯ The quality of analgesia obtained in different pediatric studies is excellent with a low rate of adverse events. L-enantiomer local anesthetics are predominantly used at low concentrations for the systemic safety provided. The use of elastomeric disposable pumps for LA infusion allows early and easy ambulation with a simplified management, bringing great satisfaction to parents and children.
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The occurrence of post-cardiac arrest syndrome may lead to death in some children who have recovered from a cardiac arrest. The post-cardiac arrest syndrome includes systemic ischaemia/reperfusion response, brain injury, myocardial dysfunction, and persistence of the precipitating pathology. ⋯ Management includes strictly control of ventilation, oxygen therapy and haemodynamics associated with protection of the brain against any secondary injury: management of seizures, control of glycaemia and central temperature. Mild hypothermia should be considered in comatose children after cardiac arrest.
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Ann Fr Anesth Reanim · Jan 2013
Review[Postoperative analgesia at home: parents' pain assessment, information].
Postoperative analgesia at home induces necessarily pain assessment by self-report or observational measure. A special scale has been validated for day-case surgery: the PPMP. Nevertheless, children's and parents' information and education are essential.