Annales françaises d'anesthèsie et de rèanimation
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Ann Fr Anesth Reanim · Sep 2010
Review[Coagulation disorders after traumatic brain injury: pathophysiology and therapeutic implications].
Early activation of coagulation is common after traumatic brain injury. Its origin is probably mainly intracerebral, due to tissue factor release from the injured brain. ⋯ Disseminated intravascular coagulation is linked to brain ischemia caused by intravascular microthrombosis. This review will focus on pathophysiology of coagulation disorders after traumatic brain injury, and on their implications for therapeutic approaches.
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Ann Fr Anesth Reanim · Sep 2010
Multicenter StudyReduction of the severe sepsis or septic shock associated mortality by reinforcement of the recommendations bundle: a multicenter study.
We determined whether the implementation of a bundle of 10 recommendations leads to the reduction of mortality in ICU patients with severe sepsis or septic shock. ⋯ The implementation of a care bundle adapted from the Surviving Sepsis Campaign guidelines decreases the 28-day mortality rate in patients with severe sepsis and/or septic shock.