Heart & lung : the journal of critical care
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Multicenter Study
Mortality, rehospitalization, and post-transplant complications in gender-mismatched heart transplant recipients.
Limited research has been published on outcomes in heart transplant (HT) recipients with gender-mismatched donors. ⋯ Female HT recipients with male donors had worse 3-year outcomes as compared to male-mismatch and no-mismatch groups.
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Pulmonary arterial hypertension (PAH) is progressive disorder characterized by elevated pulmonary vascular resistance that can lead to right heart failure and death. One of the main therapeutic options for PAH are medications targeting the prostacyclin pathway. Treprostinil is a prostacyclin analogue and selexipag is a selective IP receptor agonist. ⋯ We present two patients with PAH who received medications targeting the prostacyclin pathway and were transitioned from inhaled treprostinil to either oral treprostinil or selexipag. In both cases, we noted clinical, functional and hemodynamic deterioration. These cases highlight that the route of delivery (inhaled versus oral) and/or the specific PH medication (treprostinil versus selexipag) matter; therefore close monitoring during transitions is imperative.