Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · May 1994
Randomized Controlled Trial Comparative Study Clinical TrialEffect of beta-blockade on heart rate variability in patients with coronary artery disease.
This study assessed the effects of beta-blockade on heart rate variability in patients with coronary artery disease and determined whether the effects of metoprolol in a controlled-release formulation and atenolol differ with regard to electrocardiographic measures of cardiac autonomic control. ⋯ Beta-blockade by metoprolol and atenolol enhance the heart rate variability in patients with coronary artery disease. This may contribute to the protective effects of beta-blockade in ischemic heart disease.