Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · May 1998
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialConversion efficacy and safety of intravenous ibutilide compared with intravenous procainamide in patients with atrial flutter or fibrillation.
This multicenter study compared the efficacy and safety of ibutilide versus procainamide for conversion of recent-onset atrial flutter or fibrillation. ⋯ This study establishes the superior efficacy of ibutilide over procainamide when administered to patients to convert either atrial fibrillation or atrial flutter to sinus rhythm. Hypotension was the major adverse effect seen with procainamide. A low incidence of serious proarrhythmia was seen with the administration of ibutilide occurring at the end of infusion.
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J. Am. Coll. Cardiol. · May 1998
Multicenter Study Clinical TrialCombined oral positive inotropic and beta-blocker therapy for treatment of refractory class IV heart failure.
We sought to assess the effects of combined oral positive inotropic and beta-blocker therapy in patients with severe heart failure. ⋯ Combination therapy with a positive inotrope and a beta-blocker appears to be useful in the treatment of severe, class IV heart failure. It may be used as a palliative measure when transplantation is not an option or as a bridge to heart transplantation. Further study of this form of combined therapy is warranted.