Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Nov 2001
Randomized Controlled Trial Comparative Study Clinical TrialPotentiation of bradykinin-induced tissue plasminogen activator release by angiotensin-converting enzyme inhibition.
The aim of the present study was to determine the effect of angiotensin-converting enzyme (ACE) inhibition on the local stimulated release of tissue plasminogen activator (t-PA) from the endothelium. ⋯ We have shown a selective and marked augmentation of bradykinin-induced t-PA release during ACE inhibition. These findings suggest that the beneficial clinical and vascular effects of ACE inhibition may, in part, be mediated through local augmentation of bradykinin-induced t-PA release.