Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Jan 2003
Randomized Controlled Trial Clinical TrialAcute systemic inflammation enhances endothelium-dependent tissue plasminogen activator release in men.
The purpose of this study was to investigate in vivo the effects of acute systemic inflammation on the endogenous fibrinolytic capacity in men. ⋯ Our results showed that acute systemic inflammation augmented local forearm t-PA release in men, which suggests that acute inflammation may invoke a protective response by enhancing the acute endogenous fibrinolytic capacity in healthy men. Further studies are needed to clarify whether this response is impaired in patients with cardiovascular disease.
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J. Am. Coll. Cardiol. · Jan 2003
Randomized Controlled Trial Multicenter Study Clinical TrialRITZ-5: randomized intravenous TeZosentan (an endothelin-A/B antagonist) for the treatment of pulmonary edema: a prospective, multicenter, double-blind, placebo-controlled study.
The objective of this study was to evaluate the addition of intravenous (IV) tezosentan to standard therapy for patients with pulmonary edema. ⋯ In the present study, tezosentan (an ET-1 antagonist) did not affect the outcome of pulmonary edema, possibly because of the high dose used.