Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Feb 2004
Randomized Controlled Trial Clinical TrialLong-term effect of combined vitamins E and C on coronary and peripheral endothelial function.
We tested whether long-term administration of antioxidant vitamins C and E improves coronary and brachial artery endothelial function in patients with coronary artery disease (CAD). ⋯ Long-term oral vitamins C and E do not improve key mechanisms in the biology of atherosclerosis or endothelial dysfunction, or reduce LDL oxidation in vivo.