Journal of the American College of Cardiology

The most recent articles from: J. Am. Coll. Cardiol. October 2007

J. Am. Coll. Cardiol. · Oct 2007

Randomized Controlled Trial Multicenter Study

The effects of KW-3902, an adenosine A1-receptor antagonist,on diuresis and renal function in patients with acute decompensated heart failure and renal impairment or diuretic resistance.

This study sought to evaluate the dose-dependent effects of adenosine A1-receptor blockade on diuresis and renal function in patients with acute decompensated heart failure (ADHF) and renal impairment or diuretic resistance. ⋯ In patients with ADHF and volume overload, KW-3902, an adenosine A1-receptor antagonist, enhances the response to loop diuretics and may have a renal protective effect.

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