Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Oct 2008
Meta AnalysisRelation of beta-blocker-induced heart rate lowering and cardioprotection in hypertension.
The purpose of this study was to evaluate the role of heart rate reduction with beta-blockers on the risk of cardiovascular events in patients with hypertension. ⋯ In contrast to patients with myocardial infarction and heart failure, beta-blocker-associated reduction in heart rate increased the risk of cardiovascular events and death for hypertensive patients.