Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · May 2011
ReviewHeart failure and chronic obstructive pulmonary disease the quandary of Beta-blockers and Beta-agonists.
The combination of heart failure and chronic obstructive pulmonary disease presents many therapeutic challenges. The cornerstones of therapy are beta-blockers and beta-agonists, respectively. Their pharmacological effects are diametrically opposed, and each is purported to adversely affect the alternative condition. ⋯ Beta-agonists are associated with incident heart failure in patients with pulmonary disease and with increased mortality and hospitalization in those with existing heart failure. These purported adverse effects require further investigation. In the meantime, clinicians should consider carefully the etiology of dyspnea and obtain objective evidence of airflow obstruction before prescribing beta-agonists to patients with heart failure.
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J. Am. Coll. Cardiol. · May 2011
Review Comparative StudyCentral obesity and survival in subjects with coronary artery disease: a systematic review of the literature and collaborative analysis with individual subject data.
The aim of this study was to examine the association of central (waist circumference [WC] and waist-hip ratio [WHR]) and total obesity (body mass index [BMI]) measures with mortality in coronary artery disease (CAD) patients. ⋯ In subjects with CAD, including those with normal and high BMI, central obesity but not BMI is directly associated with mortality.
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J. Am. Coll. Cardiol. · May 2011
Review Comparative StudyCentral obesity and survival in subjects with coronary artery disease: a systematic review of the literature and collaborative analysis with individual subject data.
The aim of this study was to examine the association of central (waist circumference [WC] and waist-hip ratio [WHR]) and total obesity (body mass index [BMI]) measures with mortality in coronary artery disease (CAD) patients. ⋯ In subjects with CAD, including those with normal and high BMI, central obesity but not BMI is directly associated with mortality.