Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Feb 2014
Randomized Controlled Trial Multicenter Study Comparative StudyElevated lipoprotein(a) and risk of aortic valve stenosis in the general population.
The purpose of this study was to determine whether elevated lipoprotein(a) levels and corresponding LPA risk genotypes (rs10455872, rs3798220, kringle IV type 2 repeat polymorphism) prospectively associate with increased risk of aortic valve stenosis (AVS). ⋯ Elevated Lp(a) levels and corresponding genotypes were associated with increased risk of AVS in the general population, with levels >90 mg/dl predicting a threefold increased risk.
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J. Am. Coll. Cardiol. · Feb 2014
Randomized Controlled Trial Multicenter Study Comparative StudyImpaired systolic function by strain imaging in heart failure with preserved ejection fraction.
This study sought to determine the frequency and magnitude of impaired systolic deformation in heart failure with preserved ejection fraction (HFpEF). ⋯ Strain imaging detects impaired systolic function despite preserved global LVEF in HFpEF that may contribute to the pathophysiology of the HFpEF syndrome. (LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction; NCT00887588).