Environmental health perspectives
-
Environ. Health Perspect. · Oct 2012
Review Meta AnalysisDevelopmental fluoride neurotoxicity: a systematic review and meta-analysis.
Although fluoride may cause neurotoxicity in animal models and acute fluoride poisoning causes neurotoxicity in adults, very little is known of its effects on children's neurodevelopment. ⋯ The results support the possibility of an adverse effect of high fluoride exposure on children's neurodevelopment. Future research should include detailed individual-level information on prenatal exposure, neurobehavioral performance, and covariates for adjustment.