The Science of the total environment
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Sci. Total Environ. · Apr 2018
Randomized Controlled TrialHousehold air pollution and chronic hypoxia in the placenta of pregnant Nigerian women: A randomized controlled ethanol Cookstove intervention.
Household air pollution (HAP) is associated with adverse pregnancy outcomes. ⋯ In-utero exposure to HAP is associated with pathologic changes and HIF expression consistent with chronic hypoxia in placenta of firewood/kerosene-users compared to ethanol-users with less HAP exposure and Chicago women with no presumed HAP exposure. Presence of chronic hypoxic signature in placenta of women exposed to HAP has implications for adverse pregnancy complications and future growth and development of the young children. Future larger studies need to focus on HAP exposure and placental disorders like preeclampsia and long-term health impact of in-utero exposure to HAP.
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Sci. Total Environ. · Dec 2017
Randomized Controlled TrialHousehold air pollution and angiogenic factors in pregnant Nigerian women: A randomized controlled ethanol cookstove intervention.
Maternal exposure to ambient air pollution affects placental growth markers. ⋯ Maternal levels of PlGF and cord blood levels of sFlt-1 and PlGF in Nigerian women with varying HAP exposures were significantly higher than Chicago-based women who had no presumed HAP exposure. It suggests that in-utero exposure to HAP influenced levels of angiogenic factors involved in normal placentation and growth and could represent compensation for pollutants exposure to preserve fetal viability.