Journal of hypertension
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Journal of hypertension · Nov 2006
Randomized Controlled Trial Multicenter StudySpironolactone in type 2 diabetic nephropathy: Effects on proteinuria, blood pressure and renal function.
To study the effects of addition of spironolactone to angiotensin-converting enzyme (ACE) inhibition or angiotensin II (AngII) receptor antagonism on proteinuria, blood pressure (BP) and renal function in overt type 2 diabetic nephropathy. ⋯ Addition of spironolactone to an ACE inhibitor or AngII receptor blocker is associated with a marked and sustained antiproteinuric effect, which in part relates to the more pronounced reduction in GFR.